產(chǎn)品屬性：
產(chǎn)品名稱 | c-Di-GMP sodium salt |
規(guī)格 | 730 ug |
貨號 | EY-01Y10628 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C20H22N10Na2O14P2
分子量: 734.37
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes. This product is sold in units of 730μg, equivalent to 1μmol.Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID:23142775 |Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID:21947006 |Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID:26282097
特別提醒公司產(chǎn)品僅供科研使用
